SCHEMBL14865222

SCHEMBL14865222

Cc1ccc2c(ccn2I)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.47
HTR2C P28335 2/20 0.47
MAPT P10636 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
CYP1A2 P05177 4/20 0.44
CYP2A6 P11509 3/20 0.44
ROCK1 Q13464 1/20 0.42
TDP1 Q9NUW8 1/20 0.38
FABP4 P15090 2/20 0.38
CDK4 P11802 1/20 0.38
CCND1 P24385 1/20 0.38
MAOB P27338 1/20 0.38
TFPI2 P48307 1/20 0.36
HSP90AA1 P07900 1/20 0.35
PRKCI P41743 1/20 0.35
KDM4E B2RXH2 1/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
RAB9A P51151 1/20 0.35
PRMT5 O14744 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20614498 0.83 HTR2A (0.47) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL423394 0.76 PRKCI (0.61) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL29624271 0.76 PRKCI (0.61) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL3843657 0.74 HTR2A (0.51) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL20912282 0.74 HTR2A (0.47) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL27995207 0.74 HTR2A (0.47) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL5997555 0.74 HTR2A (0.47) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL16244710 0.74 HTR2A (0.47) HTR2AHTR2CMAPTRXFP1CYP1A2
SCHEMBL24826395 0.74 HTR2C (0.53) HTR2AHTR2CMAPTCYP1A2CYP2A6
SCHEMBL22039941 0.74 LMNA (0.35) HTR2AHTR2CPRKCIALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3892616-A1 AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND PREPARATION METHOD AND APPLICATION OF AROMATIC RING DERIVATIVE Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) 2021-10-13 EP disclosed
EP-3630780-B1 1,3-DIAZO-4-OXA-[3.3.1]-BICYCLIC DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATING DIABETES UNIV PISA (IT) 2021-06-30 EP disclosed
WO-2020141439-A1 HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) 2020-07-09 WO disclosed
EP-3170824-A1 6-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLMETHYL)-1,6-NAPHTHYRIDIN-5(6H)-ONE DERIVATIVES AS C-MET INHIBITORS Amgen, Inc (US) 2017-05-24 EP disclosed
EP-1994004-B9 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS JANSSEN PHARMACEUTICALS INC (US) 2013-04-17 EP disclosed