Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865787 | 0.89 | PRKD1 (0.51) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14866803 | 0.87 | ATR (0.67) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14865695 | 0.82 | PRKD1 (0.52) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14865823 | 0.78 | PRKD1 (0.48) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14865735 | 0.78 | PRKD1 (0.48) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14866897 | 0.77 | ATR (0.64) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14865636 | 0.76 | PRKD1 (0.46) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14865769 | 0.75 | PRKD1 (0.48) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL10178131 | 0.75 | ATR (0.54) | ATRATMPRKD1PRKD3PRKD2 | |
| SCHEMBL14865746 | 0.73 | TGFBR1 (0.41) | ATRATMPRKD1PRKD3PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130095193-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130095193-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, CHEK2 | ATR 1/4885ATM 31/4885PRKD1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.