Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516702 | 0.88 | CDK9 (0.41) | PRKD3PRKD1PRKD2CYP19A1CYP1A2 | |
| SCHEMBL4516694 | 0.88 | CDK9 (0.41) | PRKD3PRKD1PRKD2CYP19A1CYP1A2 | |
| SCHEMBL4516698 | 0.88 | CDK9 (0.41) | PRKD3PRKD1PRKD2CYP19A1CYP1A2 | |
| SCHEMBL14865914 | 0.85 | LMNA (0.42) | PRKD3PRKD1PRKD2CYP19A1F2 | |
| SCHEMBL4518368 | 0.81 | PRKD3 (0.43) | PRKD3PRKD1PRKD2ESR1ESR2 | |
| SCHEMBL4514159 | 0.81 | PRKD3 (0.45) | PRKD3PRKD1PRKD2 | |
| SCHEMBL4514167 | 0.81 | PRKD3 (0.45) | PRKD3PRKD1PRKD2 | |
| SCHEMBL4518375 | 0.81 | PRKD3 (0.43) | PRKD3PRKD1PRKD2ESR1ESR2 | |
| SCHEMBL4518381 | 0.81 | PRKD3 (0.43) | PRKD3PRKD1PRKD2ESR1ESR2 | |
| SCHEMBL4514171 | 0.81 | PRKD3 (0.45) | PRKD3PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160354372-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | THE J. DAVID GLADSTONE INSTITUTES | 2016-12-08 | — | — | US | disclosed |
| US-9359445-B2 | Compositions and methods for treating neurological disorders | THE J. DAVID GLADSTONE INSTITUTES (US) | 2016-06-07 | — | — | US | disclosed |
| US-20130095113-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | THE J. DAVID GLADSTONE INSTITUTES (US) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160354372-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | PKD2, PKD1, CKMT1A; CKMT1B | PRKD3 74/4885PRKD1 62/4885PRKD2 50/4885 |
| US-20130095113-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS | PKD2, PKD1, CKMT1A; CKMT1B | PRKD3 74/4885PRKD1 62/4885PRKD2 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.