Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HBB | P68871 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169913 | 0.77 | MCL1 (0.65) | MCL1MAPTALOX15HTTHBB | |
| SCHEMBL18227958 | 0.76 | HTT (0.52) | MCL1MAPTALOX15HTTHBB | |
| SCHEMBL22137390 | 0.76 | SRD5A2 (0.54) | MCL1POLBALDH1A1SRD5A2 | |
| Biphenyl SCHEMBL26606260 | 0.75 | TSHR (0.61) | MCL1KDM4ERAB9APOLBALDH1A1 | |
| Biphenyl SCHEMBL10897390 | 0.75 | TSHR (0.61) | MCL1KDM4ERAB9APOLBALDH1A1 | |
| SCHEMBL10500501 | 0.75 | MAPT (0.50) | MCL1MAPTALOX15HTTHBB | |
| Biphenyl SCHEMBL3046481 | 0.73 | TSHR (0.58) | MCL1KDM4ERAB9APOLBCYP2C9 | |
| Biphenyl SCHEMBL27833272 | 0.72 | POLB (0.64) | MCL1MAPTKDM4EGAARAB9A | |
| SCHEMBL7208671 | 0.72 | MAPT (0.55) | MCL1MAPTALOX15HTTHBB | |
| SCHEMBL33443 | 0.71 | SRD5A2 (0.67) | MCL1RAB9APOLBSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846747-B2 | Compounds and methods for altering lifespan of eukaryotic organisms | UNIVERSITY OF ROCHESTER (US) | 2014-09-30 | — | — | US | claimed |
| US-8846747-B2 | Compounds and methods for altering lifespan of eukaryotic organisms | UNIVERSITY OF ROCHESTER (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846747-B2 | Compounds and methods for altering lifespan of eukaryotic organisms | UNIVERSITY OF ROCHESTER (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130096175-A1 | Compounds and Methods for Altering Lifespan of Eukaryotic Organisms | SOUTHERN RESEARCH INSTITUTE (US) | 2013-04-18 | — | — | US | disclosed |
| US-20130096175-A1 | Compounds and Methods for Altering Lifespan of Eukaryotic Organisms | SOUTHERN RESEARCH INSTITUTE (US) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096175-A1 | Compounds and Methods for Altering Lifespan of Eukaryotic Organisms | HDAC5, AADAC, SIRT1 | MCL1 1137/4885MAPT 2167/4885ALOX15 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.