Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 1/20 | 0.55 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | KDM1A | O60341 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14821040 | 0.93 | SSTR3 (0.55) | SSTR3CALCRLECE1LTA4HSIRT2 | |
| SCHEMBL18494988 | 0.93 | SSTR3 (0.55) | SSTR3CALCRLECE1LTA4HSIRT2 | |
| SCHEMBL17706674 | 0.93 | SSTR3 (0.55) | SSTR3CALCRLECE1LTA4HSIRT2 | |
| SCHEMBL19231508 | 0.91 | SSTR3 (0.54) | SSTR3CALCRLECE1LTA4HSIRT2 | |
| SCHEMBL12245289 | 0.88 | SSTR3 (0.53) | SSTR3CALCRLECE1LTA4HSIRT2 | |
| SCHEMBL22096459 | 0.87 | SSTR3 (0.51) | SSTR3CALCRLLTA4HSIRT2SIRT1 | |
| SCHEMBL16479322 | 0.87 | SSTR3 (0.53) | SSTR3CALCRLLTA4HSIRT2SIRT1 | |
| SCHEMBL24101424 | 0.86 | SSTR3 (0.54) | SSTR3CALCRLLTA4HMMP3KDM1A | |
| SCHEMBL13684815 | 0.86 | SSTR3 (0.56) | SSTR3CALCRLLTA4HMMP3F2 | |
| SCHEMBL18774075 | 0.85 | SIRT2 (0.50) | SIRT2SIRT1MMP3SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558127-B1 | TARGETED PYRROLOBENZODIAZEPINE CONJUGATES | SEAGEN INC (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2021104834-A1 | COMBINATION THERAPY | ADC THERAPEUTICS SA (CH) | 2021-06-03 | — | — | WO | disclosed |
| EP-2751076-B1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | MEDIMMUNE LTD (GB) | 2018-04-25 | — | — | EP | disclosed |
| EP-2935268-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LTD (GB) | 2017-11-22 | — | — | EP | disclosed |
| WO-2017129652-A1 | PYRROLOBENZODIAZEPINES | MEDIMMUNE LIMITED (GB) | 2017-08-03 | — | — | WO | disclosed |
| EP-2751111-B1 | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases | MEDIMMUNE LTD (GB) | 2017-04-26 | — | — | EP | disclosed |
| EP-2751110-B1 | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative and autoimmune diseases | MEDIMMUNE LTD (GB) | 2017-04-19 | — | — | EP | disclosed |
| EP-2558445-B1 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES | MEDIMMUNE LTD (GB) | 2017-03-22 | — | — | EP | disclosed |
| WO-2014174111-A1 | AXL ANTIBODY-DRUG CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER | PIERRE FABRE MEDICAMENT (FR) | 2014-10-30 | — | — | WO | disclosed |
| WO-2014096365-A1 | UNSYMMETRICAL PYRROLOBENZODIAZEPINES-DIMERS FOR USE IN THE TREATMENT OF PROLIFERATIVE AND AUTOIMMUNE DISEASES | SPIROGEN SÀRL (CH) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014057118-A1 | PYRROLOBENZODIAZEPINE-ANTI-CD22 ANTIBODY CONJUGATES | ADC THERAPEUTICS SARL (CH) | 2014-04-17 | — | — | WO | disclosed |
| WO-2014057122-A1 | PYRROLOBENZODIAZEPINE-ANTI-CD22 ANTIBODY CONJUGATES | ADC THERAPEUTICS SÀRL (CH) | 2014-04-17 | — | — | WO | disclosed |
| WO-2014057115-A1 | PYRROLOBENZODIAZEPINE-ANTI-HER2 ANTIBODY CONJUGATES | ADC THERAPEUTICS SÀRL (CH) | 2014-04-17 | — | — | WO | disclosed |
| EP-2528625-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN SARL (CH) | 2013-07-10 | — | — | EP | disclosed |
| WO-2013053871-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN SÀRL (CH) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013053872-A1 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES | SPIROGEN SÀRL (CH) | 2013-04-18 | — | — | WO | disclosed |
| WO-2013053873-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN SÀRL (CH) | 2013-04-18 | — | — | WO | disclosed |