Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.50 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18752309 | 0.93 | SIRT2 (0.49) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL18752310 | 0.93 | SIRT2 (0.51) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL21097237 | 0.92 | PSMB8 (0.49) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL25863358 | 0.87 | SIRT5 (0.52) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL21097238 | 0.86 | SIRT5 (0.49) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL17039855 | 0.86 | SIRT5 (0.57) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL17750718 | 0.86 | SIRT5 (0.57) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL17750717 | 0.85 | SIRT5 (0.56) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL17039859 | 0.85 | SIRT5 (0.56) | SIRT2SIRT1SIRT3SIRT5PSMB8 | |
| SCHEMBL14872058 | 0.85 | SSTR3 (0.55) | SIRT2SIRT1SIRT3MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558127-B1 | TARGETED PYRROLOBENZODIAZEPINE CONJUGATES | SEAGEN INC (US) | 2022-01-19 | — | — | EP | disclosed |
| EP-2751111-B1 | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases | MEDIMMUNE LTD (GB) | 2017-04-26 | — | — | EP | disclosed |