Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 2/20 | 0.67 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.67 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.67 |
| ▸ | BACE1 | P56817 | 4/20 | 0.66 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 2/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14875148 | 1.00 | HSD11B1 (0.69) | HSD11B1MAOBAKR1B10AKR1B1PTGS2 | |
| SCHEMBL3401725 | 0.86 | HSD11B1 (0.62) | HSD11B1MAOBAKR1B10AKR1B1PTGS2 | |
| SCHEMBL3401728 | 0.86 | HSD11B1 (0.62) | HSD11B1MAOBAKR1B10AKR1B1PTGS2 | |
| SCHEMBL11460201 | 0.85 | POLB (0.54) | HSD11B1MAOBAKR1B10AKR1B1PTGS2 | |
| SCHEMBL28417654 | 0.84 | HSD11B1 (0.60) | HSD11B1MAOBAKR1B10AKR1B1PTGS2 | |
| SCHEMBL3402919 | 0.83 | IAPP (0.63) | HSD11B1MAOBBACE1TNFRSF1ALMNA | |
| SCHEMBL3402916 | 0.83 | IAPP (0.63) | HSD11B1MAOBBACE1TNFRSF1ALMNA | |
| SCHEMBL2126013 | 0.82 | HSD11B1 (1.00) | HSD11B1MAOBTNFRSF1ALMNATP53 | |
| SCHEMBL22596716 | 0.82 | HSD11B1 (0.75) | HSD11B1MAOBTNFRSF1ALMNATP53 | |
| SCHEMBL2126010 | 0.82 | HSD11B1 (1.00) | HSD11B1MAOBTNFRSF1ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9074238-B2 | Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease | ACADEMIA SINICA (TW) | 2015-07-07 | — | — | US | disclosed |
| US-20130102498-A1 | COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY | ACADEMIA SINICA (TW) | 2013-04-25 | — | — | US | disclosed |
| US-20130102498-A1 | COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY | ACADEMIA SINICA (TW) | 2013-04-25 | — | — | US | disclosed |