Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 3/20 | 0.63 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.49 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402919 | 1.00 | IAPP (0.63) | IAPPTRPA1HSD11B1TNFRSF1ARAB9A | |
| SCHEMBL3399802 | 0.90 | IAPP (0.65) | IAPPTRPA1HSD11B1TNFRSF1ARAB9A | |
| SCHEMBL3399806 | 0.90 | IAPP (0.65) | IAPPTRPA1HSD11B1TNFRSF1ARAB9A | |
| SCHEMBL3401728 | 0.85 | HSD11B1 (0.62) | IAPPTRPA1HSD11B1TNFRSF1AKMT2A | |
| SCHEMBL3401725 | 0.85 | HSD11B1 (0.62) | IAPPTRPA1HSD11B1TNFRSF1AKMT2A | |
| SCHEMBL20273252 | 0.84 | RAB9A (0.72) | IAPPRAB9AKMT2AMAOBNPC1 | |
| SCHEMBL28417654 | 0.84 | HSD11B1 (0.60) | TRPA1HSD11B1TNFRSF1ARAB9AKMT2A | |
| SCHEMBL27832637 | 0.84 | RAB9A (0.72) | IAPPRAB9AKMT2AMAOBNPC1 | |
| SCHEMBL19236353 | 0.84 | IAPP (0.70) | IAPPHSD11B1RAB9AKMT2AMAOB | |
| SCHEMBL14875147 | 0.83 | HSD11B1 (0.69) | HSD11B1TNFRSF1AKMT2AMAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108905-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2015-08-18 | — | — | US | disclosed |
| EP-2249820-A1 | TRPA1 ANTAGONISTS | Abbott Laboratories (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009089082-A1 | TRPA1 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2009-07-16 | — | — | WO | disclosed |
| US-20090176883-A1 | TRPA1 Antagonists | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176883-A1 | TRPA1 Antagonists | TRPA1, TRPV1, TRPV3 | IAPP 812/4885TRPA1 1/4885HSD11B1 3384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.