Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.76 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.69 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.69 |
| ▸ | PTGES | O14684 | 2/20 | 0.69 |
| ▸ | STAT3 | P40763 | 2/20 | 0.69 |
| ▸ | BACE1 | P56817 | 6/20 | 0.60 |
| ▸ | APP | P05067 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14875150 | 1.00 | KDM4E (0.76) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL14875131 | 0.89 | ALOX5 (0.79) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL13237036 | 0.89 | ALOX5 (0.79) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL30928261 | 0.88 | GAA (0.80) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL30928252 | 0.88 | GAA (0.80) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL30966316 | 0.86 | KDM4E (1.00) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL31207225 | 0.86 | KDM4E (1.00) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL29242003 | 0.86 | KDM4E (1.00) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL14875206 | 0.86 | ALOX5 (0.80) | KDM4EGAAALOX5NFE2L2PTGS1 | |
| SCHEMBL14875201 | 0.86 | ALOX5 (0.80) | KDM4EGAAALOX5NFE2L2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9074238-B2 | Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease | ACADEMIA SINICA (TW) | 2015-07-07 | — | — | US | disclosed |
| US-20130102498-A1 | COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY | ACADEMIA SINICA (TW) | 2013-04-25 | — | — | US | disclosed |