Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14875800 | 0.94 | MEN1 (0.49) | HTTLMNATP53SMN1; SMN2POLB | |
| SCHEMBL14875573 | 0.87 | PPARG (0.45) | HTTLMNAJAK3ALDH1A1KMT2A | |
| SCHEMBL16824947 | 0.85 | HTT (0.48) | HTTLMNATP53SMN1; SMN2POLB | |
| SCHEMBL14875620 | 0.83 | MAPT (0.43) | HTTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16824948 | 0.82 | KDM4E (0.54) | HTTPOLBJAK3AURKARPS6KB1 | |
| SCHEMBL14875908 | 0.81 | RXFP1 (0.40) | HTTLMNASMN1; SMN2JAK3ALDH1A1 | |
| SCHEMBL14875738 | 0.81 | RXFP1 (0.43) | HTTLMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL14875793 | 0.79 | LMNA (0.41) | HTTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL14875821 | 0.79 | ALDH1A1 (0.42) | HTTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4712695 | 0.78 | ALDH1A1 (0.65) | HTTLMNATP53SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181239-B2 | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2776434-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013059485-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| US-20130102590-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102590-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF KINASES | WEE1, WEE2, CDK1 | HTT 4272/4885LMNA 3249/4885TP53 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.