Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.49 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 4/20 | 0.46 |
| ▸ | GUSB | P08236 | 3/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877439 | 0.99 | KDM4E (0.55) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL14877387 | 0.90 | FGFR1 (0.53) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL14877017 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL14876949 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL14877168 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL14883379 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL14877134 | 0.81 | KIF11 (0.47) | HSD17B10 | |
| SCHEMBL14877438 | 0.81 | KIF11 (0.49) | IP6K1HSD17B10 | |
| SCHEMBL21666183 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL28135155 | 0.78 | GUSB (0.69) | KDM4EALDH1A1MAPTHPGDGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045437-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-06-02 | — | — | US | disclosed |
| US-9045437-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-06-02 | — | — | US | disclosed |
| US-9045437-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-06-02 | — | — | US | disclosed |
| US-9006239-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-04-14 | — | — | US | disclosed |
| US-9006239-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-04-14 | — | — | US | disclosed |
| US-9006239-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-04-14 | — | — | US | disclosed |
| US-8710064-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2014-04-29 | — | — | US | disclosed |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2014-01-16 | — | — | US | disclosed |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2014-01-16 | — | — | US | disclosed |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2014-01-16 | — | — | US | disclosed |
| US-20130310376-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2013-11-21 | — | — | US | disclosed |
| US-20130310376-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2013-11-21 | — | — | US | disclosed |
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | CHINA MEDICAL UNIVERSITY (TW) | 2013-04-25 | — | — | US | disclosed |
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | CHINA MEDICAL UNIVERSITY (TW) | 2013-04-25 | — | — | US | disclosed |
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | CHINA MEDICAL UNIVERSITY (TW) | 2013-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | AQP4, KRAS, RB1 | KDM4E 1135/4885ALDH1A1 755/4885MAPT 3279/4885 |
| US-20130310376-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CCNE2, NFE2, NR2E1 | KDM4E 51/4885ALDH1A1 1847/4885MAPT 2760/4885 |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CCNE2, RB1, NR2E1 | KDM4E 91/4885ALDH1A1 2164/4885MAPT 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.