Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 7/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531799 | 0.90 | BTK (0.39) | BTKSYKAURKAEPHB4 | |
| SCHEMBL14878015 | 0.90 | BTK (0.33) | BTKSYKAURKAHCRTR2EPHB4 | |
| SCHEMBL13531801 | 0.80 | BTK (0.40) | BTKSYKAURKAEPHB4 | |
| SCHEMBL13527004 | 0.77 | BTK (0.36) | BTKSYK | |
| SCHEMBL13531804 | 0.72 | BTK (0.51) | BTK | |
| SCHEMBL14878003 | 0.71 | BTK (0.48) | BTK | |
| SCHEMBL13531786 | 0.69 | BTK (0.39) | BTKSYK | |
| SCHEMBL14877996 | 0.68 | BTK (0.46) | BTK | |
| SCHEMBL13547730 | 0.68 | MEN1 (0.36) | AURKAEPHB4 | |
| SCHEMBL14878010 | 0.67 | BTK (0.38) | BTKSYKAURKAEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426409-B2 | 7-tert-Butyl-3-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-3H-quinazolin-4-one; arthritis; inhibit Btk | ROCHE PALO ALTO LLC (US) | 2013-04-23 | — | — | US | disclosed |