Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL598928 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL598929 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL12849555 | 0.82 | HTR2C (0.56) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL3600148 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL3600152 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL3845188 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL7273493 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL8863308 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL22184883 | 0.81 | HTR2C (0.54) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL27486429 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768825-A2 | PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES | Enanta Pharmaceuticals, Inc. (US) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013059281-A2 | PROCESSES FOR THE PREPARATION OF NOVEL BENZIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2013-04-25 | — | — | WO | disclosed |