SCHEMBL14879706

SCHEMBL14879706

C[Si](C)(O)CC(=O)Nc1cccc(C(=O)N2CCC(c3cccc(CN)c3)CC2)c1

nearest known ligand 0.59

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TPSAB1 Q15661 11/20 0.49
PARP14 Q460N5 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
KCNH2 Q12809 1/20 0.44
F10 P00742 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14879854 0.92 TPSAB1 (0.50) TPSAB1CYP3A4CYP2D6KCNH2F10
SCHEMBL19387479 0.86 TPSAB1 (0.54) TPSAB1CYP3A4CYP2D6KCNH2
SCHEMBL14879643 0.86 TPSAB1 (0.47) TPSAB1CYP3A4CYP2D6KCNH2F10
SCHEMBL18652731 0.85 TPSAB1 (0.49) TPSAB1CYP3A4CYP2D6KCNH2
SCHEMBL1668865 0.84 TPSAB1 (0.51) TPSAB1PARP14CYP3A4CYP2D6KCNH2
SCHEMBL14885397 0.83 TPSAB1 (0.55) TPSAB1CYP3A4CYP2D6KCNH2F10
SCHEMBL1668914 0.83 TPSAB1 (0.49) TPSAB1
SCHEMBL14879797 0.82 TPSAB1 (0.50) TPSAB1CYP3A4CYP2D6KCNH2
SCHEMBL14885432 0.81 TPSAB1 (0.55) TPSAB1CYP3A4CYP2D6KCNH2F10
SCHEMBL12801861 0.81 TPSAB1 (0.47) TPSAB1PARP14CYP3A4CYP2D6KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2693883-B1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME UNIV CORNELL (US) 2018-12-26 EP claimed
US-20140163229-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-06-12 US claimed
EP-2693883-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME Cornell University (US) 2014-02-12 EP claimed
WO-2013058825-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2013-04-25 WO claimed
US-10912786-B2 Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same CORNELL UNIVERSITY (US) 2021-02-09 US disclosed
US-10912786-B2 Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same CORNELL UNIVERSITY (US) 2021-02-09 US disclosed
EP-2693883-B1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME UNIV CORNELL (US) 2018-12-26 EP disclosed
US-20170080001-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY 2017-03-23 US disclosed
US-20170080001-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY 2017-03-23 US disclosed
US-20170080001-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY 2017-03-23 US disclosed
US-20140163229-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-06-12 US disclosed
US-20140163229-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-06-12 US disclosed
US-20140163229-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2014-06-12 US disclosed
EP-2693883-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME Cornell University (US) 2014-02-12 EP disclosed
WO-2013058825-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2013-04-25 WO disclosed
WO-2013058825-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME CORNELL UNIVERSITY (US) 2013-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10912786-B2 Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same STIM1, STAMBP, ILK TPSAB1 2594/4885PARP14 2318/4885CYP3A4 4313/4885
US-20170080001-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME STIM1, STAMBP, ILK TPSAB1 2594/4885PARP14 2318/4885CYP3A4 4313/4885
US-20140163229-A1 SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME STIM1, STAMBP, ILK TPSAB1 2594/4885PARP14 2318/4885CYP3A4 4313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.