SCHEMBL14880296

SCHEMBL14880296

O=C(NO)c1cccc(C(=O)c2ccccc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.72
TDP1 Q9NUW8 1/20 0.72
L3MBTL1 Q9Y468 1/20 0.72
HDAC8 Q9BY41 11/20 0.68
HDAC6 Q9UBN7 9/20 0.68
HDAC2 Q92769 6/20 0.68
HDAC1 Q13547 4/20 0.68
HDAC3 O15379 3/20 0.65
HDAC7 Q8WUI4 2/20 0.65
NCOR2 Q9Y618 2/20 0.65
CA12 O43570 1/20 0.65
CA1 P00915 1/20 0.65
IDO1 P14902 1/20 0.65
ALOX15 P16050 1/20 0.65
CA9 Q16790 1/20 0.65
HSD17B10 Q99714 1/20 0.65
KDM4E B2RXH2 1/20 0.60
EGLN2 Q96KS0 1/20 0.60
HDAC4 P56524 1/20 0.58
HDAC10 Q969S8 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11791484 0.87 HDAC8 (0.79) HDAC8HDAC6HDAC2HDAC1HDAC3
SCHEMBL14880167 0.85 HDAC8 (0.82) HDAC8HDAC6HDAC2HDAC1HDAC3
SCHEMBL135162 0.85 ATM (1.00) ATMTDP1L3MBTL1CA1HSD17B10
SCHEMBL9324919 0.85 ATM (1.00) ATMTDP1L3MBTL1CA1HSD17B10
SCHEMBL11791474 0.83 HDAC8 (0.68) L3MBTL1HDAC8HDAC6HDAC2HDAC1
SCHEMBL134024 0.83 ATM (0.95) ATMTDP1L3MBTL1HSD17B10KDM4E
SCHEMBL134300 0.83 ATM (0.95) ATMTDP1L3MBTL1HSD17B10KDM4E
SCHEMBL9848995 0.82 L3MBTL1 (0.69) ATMTDP1L3MBTL1HDAC8HDAC6
SCHEMBL21755109 0.80 HDAC8 (1.00) HDAC8HDAC6HDAC2HDAC1HDAC3
Benzohydroxamate SCHEMBL28895973 0.80 HDAC8 (1.00) HDAC8HDAC6HDAC2HDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013059582-A2 SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES NUPOTENTIAL, INC. (US) 2013-04-25 WO disclosed