Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14881098 | 0.90 | GRM4 (0.44) | KMT2AARCA1CA2ANO1 | |
| SCHEMBL18135095 | 0.84 | HPGD (0.47) | KMT2AARHPGDKDM4EALDH1A1 | |
| SCHEMBL14882659 | 0.82 | ANO1 (0.47) | KMT2AANO1NAMPTHPGDNPC1 | |
| SCHEMBL18135112 | 0.81 | ANO1 (0.49) | KMT2AANO1NAMPTNPC1ALDH1A1 | |
| SCHEMBL14875894 | 0.79 | HDAC1 (0.56) | KMT2AARCA1CA2HPGD | |
| SCHEMBL14876084 | 0.79 | KMT2A (0.51) | KMT2AARNAMPTHPGDKDM4E | |
| SCHEMBL18135116 | 0.78 | HPGD (0.52) | KMT2AARHPGDKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL14876520 | 0.78 | KMT2A (0.50) | KMT2ANAMPTHPGDKDM4EALDH1A1 | |
| SCHEMBL28823850 | 0.78 | HPGD (0.53) | KMT2AARCA1CA2HPGD | |
| SCHEMBL14875819 | 0.76 | ALDH1A1 (0.52) | KMT2AARHPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776396-A2 | HETEROARYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013057251-A2 | HETEROARYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-25 | — | — | WO | disclosed |