Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 4/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719385 | 0.82 | AKR1C2 (0.53) | CHKAAKR1C2AKR1C1RXRARXRB | |
| SCHEMBL2555248 | 0.81 | SLC6A2 (0.57) | SLC6A2SLC6A3TAAR1TRPA1 | |
| SCHEMBL448921 | 0.81 | SLC6A2 (0.57) | SLC6A2SLC6A3TAAR1TRPA1 | |
| SCHEMBL23337999 | 0.80 | TRPA1 (0.39) | AKR1C2AKR1C1SLC6A2SLC6A3MME | |
| SCHEMBL8283173 | 0.78 | TRPA1 (0.52) | MMETRPA1 | |
| SCHEMBL14884597 | 0.77 | RXRA (0.50) | AKR1C2AKR1C1RXRARXRBS1PR1 | |
| SCHEMBL412239 | 0.75 | CHKA (0.53) | CHKARXRARXRBS1PR1S1PR5 | |
| SCHEMBL14884593 | 0.75 | TP53 (0.51) | CHKAAKR1C2AKR1C1RXRARXRB | |
| SCHEMBL14884533 | 0.75 | TP53 (0.51) | CHKAAKR1C2AKR1C1RXRARXRB | |
| SCHEMBL14884526 | 0.75 | TP53 (0.51) | CHKAAKR1C2AKR1C1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114006-A1 | SUBSTITUTED BIARYL ALKYL AMIDES | BIOTHERYX, INC. | 2017-04-27 | — | — | US | disclosed |
| US-9546131-B2 | Substituted biaryl alkyl amides | BIOTHERYX, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-20140336235-A1 | SUBSTITUTED BIARYL ALKYL AMIDES | BIOTHERYX, INC. | 2014-11-13 | — | — | US | disclosed |
| US-8822527-B2 | Substituted biaryl alkyl amides | BIOTHERYX, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-20130102649-A1 | SUBSTITUTED BIARYL ALKYL AMIDES | BIOTHERYX, INC. (US) | 2013-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114006-A1 | SUBSTITUTED BIARYL ALKYL AMIDES | AADAC, NAT1, GLS2 | CHKA 1423/4885AKR1C2 524/4885AKR1C1 1214/4885 |
| US-20140336235-A1 | SUBSTITUTED BIARYL ALKYL AMIDES | AADAC, NAT1, GLS2 | CHKA 1423/4885AKR1C2 524/4885AKR1C1 1214/4885 |
| US-20130102649-A1 | SUBSTITUTED BIARYL ALKYL AMIDES | AADAC, NAT1, GLS2 | CHKA 1423/4885AKR1C2 524/4885AKR1C1 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.