Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 7/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14876234 | 0.86 | OPRL1 (0.40) | ANPEPHDAC2HDAC1OPRL1ALDH1A1 | |
| SCHEMBL14876235 | 0.80 | ANPEP (0.38) | ANPEPHDAC2OPRL1ALDH1A1LMNA | |
| SCHEMBL14875968 | 0.80 | ANPEP (0.44) | ANPEPHDAC2HDAC1ALDH1A1LMNA | |
| SCHEMBL14885551 | 0.78 | ANPEP (0.42) | ANPEPHDAC2HDAC1ALDH1A1LMNA | |
| SCHEMBL14876087 | 0.77 | ANPEP (0.47) | ANPEPHDAC2HDAC1OPRL1ALDH1A1 | |
| SCHEMBL14885690 | 0.76 | ABHD6 (0.47) | ABHD6HDAC2HDAC1GAAALDH1A1 | |
| SCHEMBL14876547 | 0.75 | ANPEP (0.44) | ANPEPHDAC1OPRL1ALDH1A1LMNA | |
| SCHEMBL20509933 | 0.66 | GAA (0.48) | ABHD6GAAALDH1A1LMNA | |
| SCHEMBL14885658 | 0.65 | ALDH1A1 (0.50) | ABHD6ALDH1A1LMNAMAPK14 | |
| SCHEMBL14885689 | 0.65 | ABHD6 (0.47) | ABHD6HDAC2HDAC1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768822-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-12-06 | — | — | EP | disclosed |
| WO-2013057013-A2 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-25 | — | — | WO | disclosed |