Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | IL2 | P60568 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 9/20 | 0.37 |
| ▸ | BRAF | P15056 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887584 | 0.90 | STIM1 (0.42) | SCN9ASTIM1ORAI1POLQIL2 | |
| SCHEMBL14885660 | 0.88 | STIM1 (0.51) | SCN9ASTIM1ORAI1POLQIL2 | |
| SCHEMBL16017226 | 0.84 | SCN9A (0.45) | SCN9ASTIM1ORAI1POLQIL2 | |
| SCHEMBL14887583 | 0.83 | SCN9A (0.43) | SCN9ASTIM1ORAI1POLQIL2 | |
| SCHEMBL17805358 | 0.82 | SMN1; SMN2 (0.51) | SCN9AKDM4ENPC1STAT1RAB9A | |
| SCHEMBL16017232 | 0.81 | SCN9A (0.45) | SCN9ASTIM1ORAI1POLQIL2 | |
| SCHEMBL16019777 | 0.81 | ALDH1A1 (0.53) | SCN9ASTIM1ORAI1NPC1RAB9A | |
| SCHEMBL14881301 | 0.81 | MEN1 (0.53) | SCN9ASTIM1ORAI1IL2KDM4E | |
| SCHEMBL14887577 | 0.80 | HSD17B10 (0.55) | SCN9ASTIM1ORAI1IL2NPC1 | |
| SCHEMBL14885664 | 0.79 | STIM1 (0.52) | SCN9ASTIM1ORAI1POLQIL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | SCN9A 235/4885STIM1 17/4885ORAI1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.