Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14890705 | 0.85 | SYK (0.44) | SYKPDK2PDK4ALDH1A1ADORA2A | |
| SCHEMBL14890407 | 0.85 | ADORA2A (0.53) | SYKNOS3NOS1NOS2ADORA2A | |
| SCHEMBL14890848 | 0.80 | SMPD3 (0.53) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL14120130 | 0.80 | SMPD3 (0.53) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL14120128 | 0.80 | SMPD3 (0.53) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL23582395 | 0.77 | MEN1 (0.36) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL27983961 | 0.77 | ADK (0.42) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL14890430 | 0.76 | ASIC3 (0.49) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 | |
| Benzene SCHEMBL27983970 | 0.75 | SYK (0.46) | SYKNOS2MAPTHPGDHIF1A | |
| SCHEMBL30003507 | 0.73 | NR1I2 (0.42) | NR1I2SMARCA2SMARCA4PBRM1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169259-B2 | Imidazopyridazine compounds | HOFFMANN-LA ROCHE INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169259-B2 | Imidazopyridazine compounds | HOFFMANN-LA ROCHE INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169259-B2 | Imidazopyridazine compounds | HOFFMANN-LA ROCHE INC. (US) | 2015-10-27 | — | — | US | disclosed |
| EP-2773645-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-10 | — | — | EP | disclosed |
| CN-104024261-A | Imidazopyridazine compounds | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |
| WO-2013064445-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013064445-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-10 | — | — | WO | disclosed |
| US-20130109661-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-20130109661-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-20130109661-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109661-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | SYK, BTK, IRAK4 | NR1I2 645/4885SMARCA2 3440/4885SMARCA4 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.