Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8478740 | 0.99 | BCHE (0.52) | BCHEACHEMAPTAPPSRC | |
| SCHEMBL8478742 | 0.99 | BCHE (0.52) | BCHEACHEMAPTAPPSRC | |
| SCHEMBL10889901 | 0.95 | BCHE (0.48) | BCHEACHEMAPTAPPSRC | |
| SCHEMBL10889909 | 0.95 | BCHE (0.48) | BCHEACHEMAPTAPPSRC | |
| Hydrochloric Acid SCHEMBL10890700 | 0.89 | BCHE (0.47) | BCHEACHEMAPTAPPSRC | |
| Hydrochloric Acid SCHEMBL10890707 | 0.89 | BCHE (0.47) | BCHEACHEMAPTAPPSRC | |
| SCHEMBL13531861 | 0.87 | MAPT (0.54) | BCHEACHEMAPTAPPKDM4E | |
| Hydrochloric Acid SCHEMBL10893665 | 0.86 | MAPT (0.45) | BCHEACHEMAPTAPPSRC | |
| SCHEMBL13005151 | 0.85 | VDR (0.49) | BCHEACHEMAPTSRCKDM4E | |
| SCHEMBL10891310 | 0.85 | MAPT (0.47) | BCHEACHEMAPTAPPSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670330-B2 | Method and dye mixtures for marking shape memory polymers, and shape memory polymer articles with switchable readability | BAM Bundesanstalt fuer Materialforschung und—Pruefung (DE) | 2017-06-06 | — | — | US | disclosed |
| US-20150119238-A1 | METHOD AND DYE MIXTURES FOR MARKING SHAPE MEMORY POLYMERS, AND SHAPE MEMORY POLYMER ARTICLES WITH SWITCHABLE READABILITY | BAM BUNDESANSTALT FUER MATERIALFORSCHUNG UND - PRUEFUNG (DE) | 2015-04-30 | — | — | US | disclosed |
| EP-2771392-A2 | METHOD AND DYE MIXTURES FOR MARKING SHAPE MEMORY POLYMERS, AND SHAPE MEMORY POLYMER ARTICLES WITH SWITCHABLE READABILITY | BAM Bundesanstalt für Materialforschung und -prüfung (DE) | 2014-09-03 | — | — | EP | disclosed |
| WO-2013060831-A2 | METHOD AND DYE MIXTURES FOR MARKING SHAPE MEMORY POLYMERS, AND SHAPE MEMORY POLYMER ARTICLES WITH SWITCHABLE READABILITY | BAM Bundesanstalt für Materialforschung und -prüfung (DE) | 2013-05-02 | — | — | WO | disclosed |