Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 7/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23021726 | 0.79 | PRKCI (0.50) | IKBKBCHUKCITROCK2ROCK1 | |
| SCHEMBL8687438 | 0.79 | CIT (0.59) | IKBKBCHUKCITROCK2ROCK1 | |
| SCHEMBL31541439 | 0.79 | PRKCI (0.50) | IKBKBCHUKCITROCK2ROCK1 | |
| SCHEMBL31541393 | 0.79 | PRKCI (0.50) | IKBKBCHUKCITROCK2ROCK1 | |
| SCHEMBL84365 | 0.79 | PRKCI (0.53) | IKBKBCHUKCITROCK2ROCK1 | |
| SCHEMBL30713630 | 0.78 | MAP2K1 (0.51) | CDK9PDPK1CDK2LRRK2AXL | |
| SCHEMBL27750328 | 0.78 | MAP2K1 (0.51) | CDK9PDPK1CDK2LRRK2AXL | |
| SCHEMBL24492983 | 0.76 | PRKCI (0.50) | IKBKBCHUKCITROCK2ROCK1 | |
| SCHEMBL8688105 | 0.76 | PRKCI (0.55) | IKBKBCHUKCITROCK2ROCK1 | |
| SCHEMBL31541422 | 0.76 | PRKCI (0.55) | IKBKBCHUKCITROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771011-A1 | CHEMICAL COMPOUNDS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-09-03 | — | — | EP | disclosed |
| WO-2013062945-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-05-02 | — | — | WO | disclosed |