Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 4/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27750328 | 1.00 | MAP2K1 (0.51) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL27678813 | 0.88 | MAP2K1 (0.54) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL4190015 | 0.87 | MAP2K1 (0.52) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL4201283 | 0.84 | MAP2K1 (0.57) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL4792749 | 0.80 | GRM8 (0.45) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL27590571 | 0.80 | AXL (0.51) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL12491066 | 0.80 | AXL (0.51) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL30068926 | 0.79 | AXL (0.55) | MAP2K1GRM8GRM4MTNR1AKMT2A | |
| SCHEMBL820352 | 0.79 | AXL (0.55) | MAP2K1GRM8GRM4MTNR1AKMT2A | |
| SCHEMBL18135257 | 0.79 | GRM8 (0.54) | MAP2K1CAMKK2GRM8GRM4MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295746-A | HPK1 inhibitor and application thereof in medicine | 贝达药业股份有限公司 | 2023-12-26 | — | — | CN | disclosed |