Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 17/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FGR | P09769 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | TIE1 | P35590 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14897511 | 0.85 | NTRK1 (0.39) | IRAK4NTRK1 | |
| SCHEMBL14897739 | 0.83 | NTRK1 (0.46) | IRAK4NTRK1JAK2INSRLYN | |
| SCHEMBL14896812 | 0.82 | NTRK1 (0.41) | IRAK4NTRK1JAK2INSRLYN | |
| SCHEMBL16193085 | 0.81 | NTRK1 (0.37) | IRAK4NTRK1JAK2INSRLYN | |
| SCHEMBL14881970 | 0.79 | NTRK1 (0.43) | IRAK4NTRK1 | |
| SCHEMBL14881453 | 0.78 | NTRK1 (0.44) | NTRK1 | |
| SCHEMBL14881516 | 0.77 | LMNA (0.43) | IRAK4NTRK1JAK2INSRLYN | |
| SCHEMBL14897003 | 0.77 | LMNA (0.43) | IRAK4NTRK1JAK2INSRLYN | |
| SCHEMBL14897403 | 0.77 | NTRK1 (0.45) | IRAK4NTRK1 | |
| SCHEMBL14896843 | 0.76 | IRAK4 (0.41) | IRAK4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013059587-A1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2013-04-25 | — | — | WO | disclosed |