Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 8/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899089 | 0.88 | ACVRL1 (0.44) | ACVRL1RIPK1MERTKAXLMET | |
| SCHEMBL14899104 | 0.84 | ACVRL1 (0.40) | ACVRL1RIPK1MERTKAXL | |
| SCHEMBL14899085 | 0.84 | ACVRL1 (0.40) | ACVRL1MERTKMETRETKDR | |
| SCHEMBL5077195 | 0.84 | CA2 (0.36) | ACVRL1RIPK1METTNK2 | |
| SCHEMBL16508304 | 0.84 | CA2 (0.36) | ACVRL1RIPK1METTNK2 | |
| SCHEMBL14899105 | 0.82 | ACVRL1 (0.49) | ACVRL1MERTK | |
| SCHEMBL14327104 | 0.81 | ACVRL1 (0.41) | ACVRL1RIPK1MERTKAXL | |
| SCHEMBL14312981 | 0.80 | ACVRL1 (0.37) | ACVRL1MERTKAXLMETTNK2 | |
| SCHEMBL5074881 | 0.79 | ACVRL1 (0.46) | ACVRL1RIPK1METTNK2 | |
| SCHEMBL14312898 | 0.79 | ACVRL1 (0.52) | ACVRL1RIPK1MERTKAXLMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431695-B2 | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-30 | — | — | US | disclosed |