Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PHPT1 | Q9NRX4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10852754 | 0.82 | CA1 (0.60) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL6689465 | 0.81 | MAPT (0.49) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL4192284 | 0.81 | ALDH1A1 (0.55) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL11720879 | 0.80 | POLB (1.00) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL2896946 | 0.80 | POLB (0.71) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL2648754 | 0.79 | CA1 (0.57) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL29651075 | 0.79 | CA1 (0.58) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL2650449 | 0.79 | HDAC1 (0.58) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL4847668 | 0.79 | CA1 (0.58) | POLBMAPTNPC1RAB9ACA1 | |
| SCHEMBL4958020 | 0.78 | MAPT (0.69) | POLBMAPTNPC1RAB9ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022048684-A1 | JNK INHIBITOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 武汉朗来科技发展有限公司 | 2022-03-10 | — | — | WO | disclosed |
| US-8431567-B2 | Substituted oxindole derivatives and their use as vasopressin and/or oxytocin receptor ligands | ABBOTT GMBH & CO. KG (DE) | 2013-04-30 | — | — | US | disclosed |