Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899380 | 0.84 | GABRA1 (0.37) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL18745640 | 0.79 | TSHR (0.58) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL5694414 | 0.77 | PDCD1 (0.43) | TSHRGABRA1GABRB2CA2PDCD1 | |
| SCHEMBL6547495 | 0.75 | TSHR (0.46) | TSHRSLC6A2TRPA1 | |
| SCHEMBL4401988 | 0.74 | TSHR (0.70) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL30606846 | 0.74 | GABRA1 (0.48) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL6055136 | 0.74 | GABRA1 (0.48) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL27391011 | 0.74 | TSHR (0.52) | TSHRGABRA1GABRG2GABRB3LMNA | |
| SCHEMBL10778159 | 0.73 | GABRA1 (0.35) | TSHRGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL9621449 | 0.72 | ADRA2A (0.38) | TSHRGABRA1GABRG2GABRB3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431573-B2 | Cyanopyrimidinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-04-30 | — | — | US | disclosed |