Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8343213 | 0.81 | PARP1 (0.43) | TNFHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL16589027 | 0.81 | ALK (0.44) | TNFHTTTSHRALKLMNA | |
| SCHEMBL17578990 | 0.80 | ALK (0.43) | HTTTSHRALKLMNASMN1; SMN2 | |
| SCHEMBL18509297 | 0.79 | PTGS1 (0.41) | HTTLMNAMAPK1MAPTMPO | |
| SCHEMBL12846383 | 0.79 | PKM (0.38) | HTTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL21143331 | 0.79 | TNF (0.48) | TNFHTTTSHRALKLMNA | |
| SCHEMBL19957477 | 0.79 | TNF (0.45) | TNFHTTTSHRLMNASMN1; SMN2 | |
| SCHEMBL14899569 | 0.79 | TNF (0.51) | TNFHTTTSHRLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27996151 | 0.79 | ALK (0.42) | HTTTSHRALKLMNASMN1; SMN2 | |
| SCHEMBL361308 | 0.79 | ALK (0.42) | TNFHTTTSHRALKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2995618-B1 | [1,2,4]TRIAZOL [4,3-A]PYRIDINE DERIVATE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN) | 2019-01-09 | — | — | EP | disclosed |
| US-20130289064-A1 | Salts and crystall forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile | NOVARTIS AG (CH) | 2013-10-31 | — | — | US | disclosed |
| US-8431592-B2 | 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase inhibitors | NOVARTIS AG (CH) | 2013-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289064-A1 | Salts and crystall forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile | AQP3, MB, TTR | TNF 4080/4885HTT 931/4885TSHR 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.