Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.43 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24706909 | 0.79 | TNNI3K (0.40) | SMN1; SMN2GAATNNI3KKDM4EALDH1A1 | |
| SCHEMBL2643186 | 0.78 | UHRF1 (0.48) | SMN1; SMN2UHRF1CCR1CCR5CCR8 | |
| SCHEMBL3675739 | 0.76 | KDM4E (0.48) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL1824530 | 0.76 | UHRF1 (0.46) | SMN1; SMN2UHRF1CCR1CCR5CCR8 | |
| SCHEMBL8434248 | 0.76 | UHRF1 (0.46) | SMN1; SMN2GAAUHRF1CCR1CCR5 | |
| SCHEMBL1464557 | 0.76 | UHRF1 (0.46) | SMN1; SMN2UHRF1CCR1CCR5CCR8 | |
| SCHEMBL30845679 | 0.76 | KDM4E (0.48) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL4637636 | 0.75 | LOXL2 (0.45) | SMN1; SMN2LMNAHTT | |
| SCHEMBL22954458 | 0.75 | JAK2 (0.43) | LMNA | |
| SCHEMBL2642943 | 0.74 | UHRF1 (0.45) | SMN1; SMN2UHRF1CCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226458-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |