Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11944588 | 0.90 | NPY5R (0.33) | POLBMCHR1 | |
| SCHEMBL11944576 | 0.86 | MAPT (0.38) | CTSKLMNAPOLB | |
| SCHEMBL11946122 | 0.84 | POLB (0.39) | KMT2ALMNAPOLBSMN1; SMN2MCHR1 | |
| SCHEMBL11945259 | 0.84 | MAPT (0.33) | POLBMCHR1 | |
| SCHEMBL11946125 | 0.84 | POLB (0.40) | KMT2ALMNAPOLBSMN1; SMN2MCHR1 | |
| SCHEMBL11946167 | 0.83 | POLB (0.38) | KMT2ALMNAPOLBSMN1; SMN2MCHR1 | |
| SCHEMBL11944592 | 0.82 | ALDH1A1 (0.32) | KMT2ALMNAPOLB | |
| SCHEMBL14899770 | 0.81 | MCHR1 (0.33) | MCHR1JAK2TP53SLC2A1SLC2A3 | |
| SCHEMBL11945257 | 0.80 | POLB (0.34) | POLBMCHR1 | |
| SCHEMBL11944569 | 0.80 | POLB (0.34) | POLBMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |