Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CASP1 | P29466 | 3/20 | 0.31 |
| ▸ | CASP7 | P55210 | 3/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058285 | 0.89 | HTR1A (0.33) | MCHR1USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11944569 | 0.87 | POLB (0.34) | MCHR1ALDH1A1CYP3A4 | |
| SCHEMBL11946126 | 0.87 | USP2 (0.34) | MCHR1USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL17058101 | 0.86 | HTR1A (0.33) | MCHR1USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14899899 | 0.83 | USP2 (0.35) | MCHR1USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11944568 | 0.82 | MAPT (0.40) | ALDH1A1CYP3A4TSHR | |
| SCHEMBL11944582 | 0.81 | MAPT (0.34) | MCHR1CYP3A4TSHR | |
| SCHEMBL14899804 | 0.81 | CTSK (0.35) | MCHR1SLC2A1SLC2A3TP53JAK2 | |
| SCHEMBL14080926 | 0.81 | MCHR1 (0.30) | MCHR1 | |
| SCHEMBL11945257 | 0.80 | POLB (0.34) | MCHR1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |