Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16510220 | 0.71 | MAPT (0.41) | MAPTMEN1KMT2AALOX15GAA | |
| SCHEMBL16864517 | 0.68 | JAK2 (0.38) | MAPTMEN1KMT2AALOX15GAA | |
| SCHEMBL14846473 | 0.68 | EGFR (0.33) | MAPTMEN1KMT2AALOX15GAA | |
| SCHEMBL14567926 | 0.68 | MEN1 (0.45) | MEN1KMT2AGAACREBBPALDH1A1 | |
| SCHEMBL2638823 | 0.67 | CCKBR (0.40) | IDO1 | |
| SCHEMBL13892507 | 0.67 | MEN1 (0.37) | MAPTMEN1KMT2AALOX15GAA | |
| SCHEMBL28923189 | 0.67 | HTR2A (0.48) | KMT2AKDM4ETP53HSD17B10LMNA | |
| SCHEMBL1600166 | 0.66 | CREBBP (0.40) | MAPTMEN1KMT2AALOX15GAA | |
| SCHEMBL24289281 | 0.66 | MEN1 (0.39) | MAPTMEN1KMT2AALOX15GAA | |
| SCHEMBL12379793 | 0.66 | HTR2A (0.41) | MAPTMEN1KMT2AALOX15GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |