Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565308 | 0.79 | KDM4E (0.44) | GPR142SLC6A3KDM4ECAPN1FOLH1 | |
| SCHEMBL14280926 | 0.78 | GPR142 (0.37) | GPR142SLC6A3KDM4ECAPN1FOLH1 | |
| SCHEMBL990478 | 0.75 | DPP4 (0.49) | GPR142SLC6A3KDM4EDPP4DPP8 | |
| SCHEMBL22193474 | 0.75 | GPR142 (0.40) | GPR142SLC6A3KDM4ECAPN1FOLH1 | |
| SCHEMBL990477 | 0.75 | DPP4 (0.49) | GPR142SLC6A3KDM4EDPP4DPP8 | |
| SCHEMBL6897379 | 0.75 | GPR142 (0.40) | GPR142SLC6A3KDM4ECAPN1FOLH1 | |
| SCHEMBL6897376 | 0.75 | GPR142 (0.40) | GPR142SLC6A3KDM4ECAPN1FOLH1 | |
| SCHEMBL5535517 | 0.75 | GPR142 (0.40) | GPR142SLC6A3KDM4ECAPN1FOLH1 | |
| SCHEMBL14561302 | 0.75 | GPR142 (0.40) | GPR142SLC6A3KDM4ECAPN1FOLH1 | |
| SCHEMBL5907044 | 0.75 | DPP4 (0.49) | GPR142SLC6A3KDM4EDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948678-B1 | Compounds for enzyme inhibition | ONYX THERAPEUTICS INC (US) | 2013-05-01 | — | — | EP | disclosed |