Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | APAF1 | O14727 | 1/20 | 0.67 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.66 |
| ▸ | MITF | O75030 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.62 |
| ▸ | TCF4 | P15884 | 1/20 | 0.62 |
| ▸ | DVL1 | O14640 | 1/20 | 0.62 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PLEC | Q15149 | 1/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.58 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12008625 | 0.96 | CTNNB1 (0.69) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008627 | 0.94 | APAF1 (0.66) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008528 | 0.94 | FABP4 (0.78) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008497 | 0.93 | CTNNB1 (0.73) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008421 | 0.93 | CTNNB1 (0.73) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008549 | 0.93 | FABP4 (0.85) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008416 | 0.92 | CTNNB1 (0.75) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL13446874 | 0.91 | FABP4 (0.60) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008418 | 0.89 | CTNNB1 (0.76) | FABP4KMT2AAPAF1ADAMTS5MAPT | |
| SCHEMBL12008511 | 0.89 | CTNNB1 (0.78) | FABP4KMT2AAPAF1ADAMTS5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
| US-9433611-B2 | Oxazole and thiazole compounds as β-catenin modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2016-09-06 | — | — | US | disclosed |
| US-9433611-B2 | Oxazole and thiazole compounds as β-catenin modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2016-09-06 | — | — | US | disclosed |
| US-20130109675-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | NEW YORK UNIVERSITY | 2013-05-02 | — | — | US | disclosed |
| US-20130109675-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | NEW YORK UNIVERSITY | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNNA1, CTNNBL1 | FABP4 1744/4885KMT2A 4591/4885APAF1 2916/4885 |
| US-20130109675-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNNA1, CTNNBL1 | FABP4 1744/4885KMT2A 4591/4885APAF1 2916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.