Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25160198 | 0.91 | MAPT (0.47) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL9665148 | 0.87 | MAPT (0.77) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL20639915 | 0.87 | MAPT (0.58) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL12240584 | 0.87 | MAPT (0.80) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL19730460 | 0.87 | MAPT (0.80) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL9664895 | 0.85 | MAPT (0.78) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL6941180 | 0.84 | ALDH1A1 (0.55) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL13116055 | 0.83 | DGAT1 (0.51) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL13114922 | 0.82 | DGAT1 (0.57) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL13114760 | 0.81 | DGAT1 (0.59) | MAPTKDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9072660-B2 | Topical itraconazole formulations and uses thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130109700-A1 | Topical Itraconazole Formulations and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109700-A1 | Topical Itraconazole Formulations and Uses Thereof | CYP51A1, GABBR1, KRT18 | MAPT 1308/4885KDM4E 4093/4885ALDH1A1 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.