Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | GHSR | Q92847 | 2/20 | 0.46 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Segetalin D SCHEMBL151348 | 0.87 | HDAC4 (0.54) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL29412929 | 0.81 | HDAC4 (0.54) | HDAC4GHSR | |
| SCHEMBL24614262 | 0.80 | HDAC4 (0.66) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL31094302 | 0.79 | SMN1; SMN2 (0.61) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL12392880 | 0.78 | HDAC4 (0.69) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL14206285 | 0.78 | HDAC4 (0.69) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL12368077 | 0.78 | HDAC4 (0.69) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL29666557 | 0.78 | HDAC4 (0.55) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL22192939 | 0.76 | SOAT2 (0.45) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| Pseudostellarin H SCHEMBL31295693 | 0.76 | KEAP1 (0.55) | HDAC4HDAC1GHSRKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430162-A1 | DNA SEQUENCES ENCODING CARYOPHYLLACEAE AND CARYOPHYLLACEAE-LIKE CYCLOPEPTIDE PRECURSORS AND METHODS OF USE | National Research Council of Canada (CA) | 2012-03-21 | — | — | EP | disclosed |
| US-20120058905-A1 | DNA Sequences Encoding Caryophyllaceae and Caryophyllaceae-Like Cyclopeptide Precursors and Methods of Use | COVELLO PATRICK S (CA) | 2012-03-08 | — | — | US | disclosed |
| WO-2010130030-A1 | DNA SEQUENCES ENCODING CARYOPHYLLACEAE AND CARYOPHYLLACEAE-LIKE CYCLOPEPTIDE PRECURSORS AND METHODS OF USE | NATIONAL RESEARCH COUNSIL OF CANADA (CA) | 2010-11-18 | — | — | WO | disclosed |