Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.83 |
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | PKM | P14618 | 3/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.60 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16035440 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL16035441 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL11140025 | 0.85 | KDM4E (0.81) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL11140030 | 0.85 | KDM4E (0.81) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL8980054 | 0.82 | ALDH1A1 (0.70) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL11600676 | 0.81 | ALDH1A1 (0.68) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL5177416 | 0.79 | KDM4E (0.77) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL9314178 | 0.79 | KDM4E (0.77) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL5176156 | 0.79 | KDM4E (0.77) | ALDH1A1HPGDMEN1CYP2C9KMT2A | |
| SCHEMBL6546458 | 0.79 | KDM4E (0.77) | ALDH1A1HPGDMEN1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873661-B2 | Small molecule malarial Aldolase-TRAP enhancers and glideosome inhibitors | NEW YORK UNIVERSITY (US) | 2018-01-23 | — | — | US | disclosed |
| US-20140275088-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | THE JOHNS HOPKINS UNIVERSITY | 2014-09-18 | — | — | US | disclosed |
| WO-2013063243-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | NEW YORK UNIVERSITY (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275088-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | ALDOA, DERA, TALDO1 | ALDH1A1 204/4885HPGD 2130/4885MEN1 1882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.