Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 5/20 | 0.66 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14890641 | 0.88 | LIPE (0.62) | LIPESMN1; SMN2PRMT5KMT2AALDH1A1 | |
| SCHEMBL14907137 | 0.86 | LIPE (0.55) | LIPENOD1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16239255 | 0.86 | TNF (0.55) | LIPETNFNOD2NOD1GAA | |
| SCHEMBL16238884 | 0.83 | LIPE (0.51) | LIPENAMPT | |
| SCHEMBL14890633 | 0.82 | LIPE (0.73) | LIPETNFNOD2NOD1SMN1; SMN2 | |
| SCHEMBL16239253 | 0.82 | NPC1 (0.55) | LIPETNFNOD2NOD1SMN1; SMN2 | |
| SCHEMBL20869364 | 0.80 | CYP2D6 (0.49) | LIPENOD1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16251376 | 0.80 | LIPE (0.50) | LIPETNFNOD2NOD1SMN1; SMN2 | |
| SCHEMBL7557024 | 0.80 | LIPE (1.00) | LIPEPRMT5GAAKMT2AMEN1 | |
| Benzenesulfonamide SCHEMBL16238901 | 0.79 | CA1 (0.56) | LIPESMN1; SMN2PRMT5GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546426-B2 | N-aminotetrahydroisoquinolines as anti-cancer agents | Florida A&M University Board of Trustees (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130109716-A1 | N-AMINOTETRAHYDROISOQUINOLINES AS ANTI-CANCER AGENTS | Florida A&M University Board of Trustees (US) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109716-A1 | N-AMINOTETRAHYDROISOQUINOLINES AS ANTI-CANCER AGENTS | TNS4, BRCA1, MKI67 | LIPE 4473/4885TNF 4583/4885NOD2 4300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.