Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16425378 | 0.98 | TSHR (0.41) | TSHRHPGDPLA2G4BPTPN2PTPN6 | |
| SCHEMBL12567819 | 0.97 | TSHR (0.41) | TSHRHPGDPLA2G4BPTPN2THRB | |
| SCHEMBL10534921 | 0.96 | THRB (0.42) | TSHRHPGDPTPN2HRH2HRH1 | |
| SCHEMBL14907456 | 0.94 | PTPN2 (0.42) | TSHRHPGDPTPN2PTPN6PTPN11 | |
| SCHEMBL16133502 | 0.94 | PTPN2 (0.42) | TSHRHPGDPTPN2PTPN6PTPN11 | |
| SCHEMBL14255568 | 0.94 | TSHR (0.44) | TSHRHPGDPLA2G4BPTPN2THRB | |
| SCHEMBL18328875 | 0.94 | TSHR (0.44) | TSHRHPGDPLA2G4BPTPN2THRB | |
| SCHEMBL16425384 | 0.92 | PTPN2 (0.41) | TSHRHPGDPTPN2PTPN6PTPN11 | |
| SCHEMBL12087289 | 0.91 | PTPN2 (0.43) | TSHRHPGDPTPN2PTPN6PTPN11 | |
| SCHEMBL12567693 | 0.91 | ALDH1A1 (0.37) | TSHRHPGDHRH2HRH1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771735-B1 | SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2018-01-24 | — | — | EP | disclosed |
| US-9507185-B2 | Switch element comprising a liquid crystalline medium | MERCK PATENT GMBH (DE) | 2016-11-29 | — | — | US | disclosed |
| US-9507185-B2 | Switch element comprising a liquid crystalline medium | MERCK PATENT GMBH (DE) | 2016-11-29 | — | — | US | disclosed |
| US-20140293174-A1 | SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| US-20140293174-A1 | SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2014-10-02 | — | — | US | disclosed |
| WO-2013060406-A1 | SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2013-05-02 | — | — | WO | disclosed |