Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14907695 | 0.79 | JAK2 (0.38) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL14907704 | 0.78 | MET (0.38) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL16141576 | 0.78 | PTK2 (0.38) | ROCK1RETJAK2AURKBIKBKB | |
| Hydrochloric Acid SCHEMBL538973 | 0.76 | PRKCI (0.42) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL4974852 | 0.71 | NUDT1 (0.41) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL4974854 | 0.71 | NUDT1 (0.41) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL14907662 | 0.70 | NUDT1 (0.44) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL14894258 | 0.70 | JAK2 (0.40) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL14907843 | 0.70 | IKBKB (0.40) | ROCK1RETJAK2AURKBIKBKB | |
| SCHEMBL14894261 | 0.70 | MEN1 (0.51) | JAK2PRKCIAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013062945-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-05-02 | — | — | WO | disclosed |