Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 5/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 5/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14894031 | 0.93 | VCP (0.50) | VCPGFERBRAFBTKCIT | |
| SCHEMBL14894201 | 0.91 | VCP (0.48) | VCPGFERBRAFBTKCIT | |
| SCHEMBL16141489 | 0.89 | BRAF (0.49) | VCPBRAFBTKROCK2 | |
| SCHEMBL14907671 | 0.87 | VCP (0.44) | VCPGFERBRAFBTKRET | |
| SCHEMBL14894298 | 0.87 | VCP (0.48) | VCPGFERBRAFBTKCIT | |
| SCHEMBL14894414 | 0.86 | VCP (0.46) | VCPGFERBRAFBTKCIT | |
| SCHEMBL14894064 | 0.86 | VCP (0.46) | VCPGFERBRAFBTKCIT | |
| SCHEMBL16107729 | 0.86 | VCP (0.46) | VCPGFERBRAFBTKCIT | |
| SCHEMBL14907713 | 0.86 | VCP (0.46) | VCPGFERBRAFBTKCIT | |
| SCHEMBL14894183 | 0.83 | NPC1 (0.42) | VCPBRAFCITROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174984-B2 | Chemical compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-11-03 | — | — | US | disclosed |
| US-20140296204-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2014-10-02 | — | — | US | disclosed |
| WO-2013062945-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296204-A1 | CHEMICAL COMPOUNDS | DNMT1, DNMT3A, DNMT3B | VCP 4187/4885GFER 2800/4885BRAF 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.