Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14894201 | 0.94 | VCP (0.48) | VCPRAB9ABRAFHPGDMAOB | |
| SCHEMBL14894239 | 0.92 | ALOX12 (0.42) | VCPBRAFHPGDLMNABTK | |
| SCHEMBL16141489 | 0.91 | BRAF (0.49) | VCPBRAFBTKKMT2AMEN1 | |
| SCHEMBL14894031 | 0.89 | VCP (0.50) | VCPBRAFBTKRETKMT2A | |
| SCHEMBL14907714 | 0.87 | VCP (0.48) | VCPBRAFBTKRETGFER | |
| SCHEMBL14894069 | 0.86 | VCP (0.37) | VCPRET | |
| SCHEMBL14894298 | 0.83 | VCP (0.48) | VCPBRAFHPGDBTKALDH1A1 | |
| SCHEMBL14907668 | 0.83 | VCP (0.37) | VCPBTKRET | |
| SCHEMBL14894295 | 0.82 | BTK (0.42) | RAB9ABRAFBTKRETKMT2A | |
| SCHEMBL14894064 | 0.82 | VCP (0.46) | VCPBRAFBTKRETGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013062945-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-05-02 | — | — | WO | disclosed |