Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.81 |
| ▸ | GAA | P10253 | 10/20 | 0.81 |
| ▸ | GLA | P06280 | 9/20 | 0.81 |
| ▸ | HPGD | P15428 | 7/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.81 |
| ▸ | THRB | P10828 | 1/20 | 0.81 |
| ▸ | CASP1 | P29466 | 9/20 | 0.76 |
| ▸ | CASP7 | P55210 | 9/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.76 |
| ▸ | KPNA2 | P52292 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.69 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16171057 | 0.87 | GRK6 (0.77) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL14907744 | 0.80 | GRK6 (1.00) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL14907745 | 0.79 | GRK6 (1.00) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL8168686 | 0.71 | CASP1 (0.72) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL20485724 | 0.70 | FYN (1.00) | KDM4EALDH1A1GAAGLAHPGD | |
| SCHEMBL16171058 | 0.69 | GRK6 (0.77) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL22954308 | 0.69 | FYN (0.64) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL16171183 | 0.68 | GRK6 (0.78) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL5524666 | 0.68 | TSHR (0.65) | GRK6KDM4EALDH1A1GAAGLA | |
| SCHEMBL22954310 | 0.66 | HSD17B10 (0.49) | GRK6KDM4EALDH1A1GAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10252984-B2 | Inhibiting G protein coupled receptor 6 kinase polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2019-04-09 | — | — | US | disclosed |
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2014-10-16 | — | — | US | disclosed |
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2014-10-16 | — | — | US | disclosed |
| WO-2013063458-A2 | INHIBITING G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | GRK6, GRK2, GRK3 | GRK6 1/4885KDM4E 4504/4885ALDH1A1 4731/4885 |
| US-10252984-B2 | Inhibiting G protein coupled receptor 6 kinase polypeptides | GRK6, GRK2, GRK3 | GRK6 1/4885KDM4E 4504/4885ALDH1A1 4731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.