Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.77 |
| ▸ | GLA | P06280 | 9/20 | 0.77 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.77 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.72 |
| ▸ | HPGD | P15428 | 14/20 | 0.72 |
| ▸ | GAA | P10253 | 12/20 | 0.72 |
| ▸ | MAPT | P10636 | 9/20 | 0.72 |
| ▸ | NSD2 | O96028 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.71 |
| ▸ | CASP1 | P29466 | 9/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14907745 | 0.99 | GRK6 (1.00) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL16171058 | 0.87 | GRK6 (0.77) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL16171183 | 0.86 | GRK6 (0.78) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL14907727 | 0.80 | GRK6 (1.00) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL6980640 | 0.79 | GRK6 (0.70) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL18153563 | 0.78 | KDM4E (0.74) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL15032613 | 0.73 | KDM4E (1.00) | KDM4EGLASAE1UBA2ALDH1A1 | |
| SCHEMBL29365795 | 0.73 | KDM4E (0.69) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL1813777 | 0.73 | KDM4E (0.69) | GRK6KDM4EGLASAE1UBA2 | |
| SCHEMBL9162749 | 0.72 | ALDH1A1 (0.57) | GRK6KDM4EGLASAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10252984-B2 | Inhibiting G protein coupled receptor 6 kinase polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2019-04-09 | — | — | US | disclosed |
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2014-10-16 | — | — | US | disclosed |
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2014-10-16 | — | — | US | disclosed |
| WO-2013063458-A2 | INHIBITING G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | GRK6, GRK2, GRK3 | GRK6 1/4885KDM4E 4504/4885GLA 2667/4885 |
| US-10252984-B2 | Inhibiting G protein coupled receptor 6 kinase polypeptides | GRK6, GRK2, GRK3 | GRK6 1/4885KDM4E 4504/4885GLA 2667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.