Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 2/20 | 0.67 |
| ▸ | SLC5A2 | P31639 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 6/20 | 0.44 |
| ▸ | CA2 | P00918 | 6/20 | 0.44 |
| ▸ | PYGB | P11216 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16171111 | 0.81 | GRK6 (1.00) | GRK6TSHRCA1CA2 | |
| SCHEMBL6672229 | 0.78 | TSHR (0.70) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL30003604 | 0.78 | TSHR (0.70) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL14907930 | 0.77 | TSHR (0.54) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL11317273 | 0.76 | TSHR (0.56) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL11317267 | 0.76 | TSHR (0.56) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL17612649 | 0.73 | GRK6 (0.50) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL17612651 | 0.70 | GRK6 (0.44) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL17612672 | 0.70 | GRK6 (0.47) | GRK6SLC5A2TSHRNPC1RAB9A | |
| SCHEMBL18520000 | 0.69 | ADK (0.48) | GRK6SLC5A2TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2014-10-16 | — | — | US | disclosed |
| WO-2013063458-A2 | INHIBITING G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309185-A1 | Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides | GRK6, GRK2, GRK3 | GRK6 1/4885SLC5A2 4216/4885TSHR 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.