Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.47 |
| ▸ | NOS3 | P29474 | 5/20 | 0.47 |
| ▸ | NOS2 | P35228 | 5/20 | 0.47 |
| ▸ | NOS1 | P29475 | 3/20 | 0.47 |
| ▸ | F12 | P00748 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | IL5 | P05113 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10144228 | 0.85 | MAPT (0.48) | ROCK1NOS3NOS2NOS1F12 | |
| SCHEMBL19496863 | 0.82 | WNT3A (0.55) | ROCK1MAP4K4 | |
| SCHEMBL26968115 | 0.80 | ROCK1 (0.50) | ROCK1NOS3NOS2NOS1F12 | |
| SCHEMBL30107363 | 0.80 | ROCK1 (0.50) | ROCK1NOS3NOS2NOS1F12 | |
| SCHEMBL10078326 | 0.80 | CYP2A6 (0.50) | CYP1A2CYP2A6UHRF1IL5 | |
| SCHEMBL28941499 | 0.78 | ROCK1 (0.49) | ROCK1NOS3NOS2NOS1F12 | |
| SCHEMBL19497082 | 0.77 | CYP2A6 (0.44) | CYP1A2CYP2A6UHRF1IL5MAPT | |
| SCHEMBL17051661 | 0.77 | CYP1A2 (0.56) | CYP1A2CYP2A6UHRF1IL5MAPT | |
| SCHEMBL25794807 | 0.77 | ROCK1 (0.44) | ROCK1NOS3NOS2NOS1F12 | |
| SCHEMBL9984740 | 0.77 | ROCK1 (0.44) | ROCK1NOS3NOS2NOS1F12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729150-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2016-09-14 | — | — | EP | disclosed |
| US-9161924-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-10-20 | — | — | US | disclosed |
| US-8980916-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140322195-A1 | Factor IXA Inhibitors | MERCK SHARP & DOHME LLC | 2014-10-30 | — | — | US | disclosed |
| US-20140219989-A1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2014-08-07 | — | — | US | disclosed |
| WO-2013063068-A1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140219989-A1 | FACTOR IXA INHIBITORS | F9, F12, F11 | ROCK1 306/4885NOS3 2586/4885NOS2 2891/4885 |
| US-20140322195-A1 | Factor IXA Inhibitors | F9, F12, F11 | ROCK1 306/4885NOS3 2586/4885NOS2 2891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.