Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.49 |
| ▸ | PGR | P06401 | 3/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754989 | 0.81 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2POLBNR3C1PGR | |
| SCHEMBL29398556 | 0.78 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2POLBNR3C1PGR | |
| SCHEMBL6840090 | 0.77 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2POLBNR3C1PGR | |
| SCHEMBL11949257 | 0.76 | SMN1; SMN2 (0.65) | ALDH1A1SMN1; SMN2POLBNR3C1PGR | |
| SCHEMBL29522198 | 0.76 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2POLBHPGDKEAP1 | |
| SCHEMBL1677059 | 0.76 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2POLBHPGDKEAP1 | |
| SCHEMBL334530 | 0.76 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2POLBHPGDKEAP1 | |
| SCHEMBL8563551 | 0.75 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2POLBNR3C1PGR | |
| SCHEMBL3560486 | 0.75 | POLB (0.73) | ALDH1A1SMN1; SMN2POLBHPGD | |
| SCHEMBL1490804 | 0.74 | NPSR1 (0.48) | ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897609-B2 | Aryl substituted imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2011-03-01 | — | — | US | disclosed |