Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | ILK | Q13418 | 2/20 | 0.40 |
| ▸ | MPL | P40238 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14910287 | 0.80 | MPL (0.56) | MPL | |
| SCHEMBL7254336 | 0.79 | NPSR1 (0.40) | ILKMPLMEN1KMT2A | |
| SCHEMBL14911096 | 0.76 | IDO1 (0.55) | NOTUMAGPAT2JAK2HPGDKDM4E | |
| SCHEMBL14910868 | 0.76 | KIF11 (0.47) | NOTUMKDM4ENPC1 | |
| SCHEMBL1857868 | 0.74 | NPC1 (0.54) | NOTUMHPGDKDM4ENPC1GAA | |
| SCHEMBL22659826 | 0.73 | NOTUM (0.42) | NOTUMAGPAT2JAK2MPLKDM4E | |
| SCHEMBL2445966 | 0.72 | ILK (0.48) | IKBKBILKKDM4EBACE1 | |
| SCHEMBL1914851 | 0.72 | IDO1 (0.56) | NOTUMIKBKBMEN1KMT2A | |
| SCHEMBL14910950 | 0.72 | NOTUM (0.50) | NOTUMIKBKBMPLHPGDKDM4E | |
| SCHEMBL14910385 | 0.70 | TLR8 (0.42) | ILKKDM4ENPC1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118067-B1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SIENA BIOTECH SPA (IT) | 2013-05-08 | — | — | EP | disclosed |