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Sugi Predict / Compounds / SCHEMBL14912467

SCHEMBL14912467

SCHEMBL14912467

CC1CN(C(=O)OC(C)(C)C)CCN1c1ccc(N)nc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ SMARCA2 P51531 1/20 0.54
▸ SMARCA4 P51532 1/20 0.54
▸ PBRM1 Q86U86 1/20 0.54
▸ GPR119 Q8TDV5 13/20 0.52
▸ LMNA P02545 1/20 0.45
▸ TP53 P04637 1/20 0.45
▸ THRB P10828 1/20 0.45
▸ MET P08581 1/20 0.43
▸ ADAMTS5 Q9UNA0 1/20 0.43
▸ ALOX5AP P20292 1/20 0.41
▸ FEN1 P39748 1/20 0.41
▸ ABCB1 P08183 1/20 0.41
▸ MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14912289 1.00 SMARCA2 (0.54) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL30512308 1.00 SMARCA2 (0.54) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL14924376 1.00 SMARCA2 (0.54) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL30176849 1.00 SMARCA2 (0.54) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL14927204 0.87 GPR119 (0.54) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL25707196 0.87 GPR119 (0.54) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL24375328 0.87 GPR119 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL28855340 0.87 GPR119 (0.53) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL31247616 0.86 GPR119 (0.52) SMARCA2SMARCA4PBRM1GPR119LMNA
SCHEMBL30578907 0.86 SMARCA2 (0.43) SMARCA2SMARCA4PBRM1GPR119ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117897388-A BTK protein degradation agent 广州麓鹏制药有限公司 2024-04-16 — — CN disclosed
US-20230279012-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS GENENTECH, INC. (US) 2023-09-07 — — US disclosed
CN-115785097-A BTK inhibitor and application thereof 乳源东阳光药业有限公司 2023-03-14 — — CN disclosed
EP-4050012-A1 PYRIDONE BORONATES FOR THE PREPARATION OF INHIBITORS OF BTK ACTIVITY F. Hoffmann-La Roche AG (CH) 2022-08-31 — — EP disclosed
EP-4019508-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY F. Hoffmann-La Roche AG (CH) 2022-06-29 — — EP disclosed
EP-3521288-B1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY HOFFMANN LA ROCHE (CH) 2021-09-08 — — EP disclosed
US-20210079002-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS GENENTECH, INC. (US) 2021-03-18 — — US disclosed
US-RE48239-E1 Heteroaryl pyridone and aza-pyridone compounds GENETECH, INC. (US) 2020-10-06 — — US disclosed
US-20200062769-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS GENENTECH, INC. (US) 2020-02-27 — — US disclosed
CN-107011348-B Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity 霍夫曼-拉罗奇有限公司 2020-01-10 — — CN disclosed
CN-104125959-A Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity HOFFMANN LA ROCHE 2014-10-29 — — CN disclosed
EP-2773639-A1 ALKYLATED PIPERAZINE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY F.HOFFMANN-LA ROCHE AG (CH) 2014-09-10 — — EP disclosed
US-20140194408-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS GENENTECH, INC. (US) 2014-07-10 — — US disclosed
US-8754077-B2 8-fluorophthalazin-1(2H)-one compounds F. HOFFMANN-LA ROCHE AG (CH) 2014-06-17 — — US disclosed
US-20140128401-A1 8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS GENENTECH, INC. (US) 2014-05-08 — — US disclosed
US-8716274-B2 Heteroaryl pyridone and aza-pyridone compounds GENENTECH, INC. (US) 2014-05-06 — — US disclosed
US-8669251-B2 8-fluorophthalazin-1(2H)-one compounds GENENTECH, INC. (US) 2014-03-11 — — US disclosed
WO-2013067277-A1 ALKYLATED PIPERAZINE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY GENENTECH, INC. (US) 2013-05-10 — — WO disclosed
US-20130116235-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS GENENTECH, INC. (US) 2013-05-09 — — US disclosed
US-20130116246-A1 8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS GENENTECH, INC. (US) 2013-05-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130116246-A1 8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS BTK, LCK, SYK SMARCA2 3741/4885SMARCA4 3956/4885PBRM1 1059/4885
US-20200062769-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS PDXK, BTK, TYK2 SMARCA2 2590/4885SMARCA4 2211/4885PBRM1 909/4885
US-20140128401-A1 8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS BTK, LCK, SYK SMARCA2 4056/4885SMARCA4 3856/4885PBRM1 852/4885
US-20230279012-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS PDXK, BTK, TYK2 SMARCA2 2590/4885SMARCA4 2211/4885PBRM1 909/4885
US-20130116235-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS BTK, PDXK, TYK2 SMARCA2 2828/4885SMARCA4 2335/4885PBRM1 1076/4885
US-20140194408-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS BTK, PDXK, TYK2 SMARCA2 2828/4885SMARCA4 2335/4885PBRM1 1076/4885
US-20210079002-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS PDXK, BTK, TYK2 SMARCA2 2590/4885SMARCA4 2211/4885PBRM1 909/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.