Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491687 | 1.00 | ALDH1A1 (0.47) | ALDH1A1HTTHDAC1HDAC6HDAC3 | |
| SCHEMBL12673060 | 0.90 | HDAC1 (0.50) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL1491544 | 0.87 | HDAC1 (0.49) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL1491537 | 0.87 | HDAC1 (0.49) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL19716963 | 0.86 | ITGB3 (0.43) | ALDH1A1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL19716961 | 0.86 | ITGB3 (0.43) | ALDH1A1HDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL1491650 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HTTHDAC1HDAC6HDAC3 | |
| SCHEMBL1491649 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HTTHDAC1HDAC6HDAC3 | |
| SCHEMBL1491646 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HTTHDAC1HDAC6HDAC3 | |
| SCHEMBL1491721 | 0.83 | HDAC1 (0.46) | ALDH1A1HTTHDAC1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133104-B2 | Enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2015-09-15 | — | — | US | disclosed |
| US-20140163042-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2014-06-12 | — | — | US | disclosed |
| US-20130116318-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2013-05-09 | — | — | US | disclosed |
| EP-1879895-B1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-06-08 | — | — | EP | disclosed |
| US-7939666-B2 | Enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-05-10 | — | — | US | disclosed |
| EP-2301939-A1 | Enzyme inhibitors | Chroma Therapeutics Limited (GB) | 2011-03-30 | — | — | EP | disclosed |
| US-20090291978-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-11-26 | — | — | US | disclosed |
| EP-1879895-A1 | ENZYME INHIBITORS | Chroma Therapeutics Limited (GB) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117549-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116318-A1 | Enzyme Inhibitors | HDAC1, HDAC11, HDAC7 | ALDH1A1 220/4885HTT 3600/4885HDAC1 1/4885 |
| US-20140163042-A1 | ENZYME INHIBITORS | HAT1, NR2E1, HDAC3 | ALDH1A1 723/4885HTT 4755/4885HDAC1 5/4885 |
| US-20090291978-A1 | Enzyme Inhibitors | HAT1, NR2E1, NR2C2 | ALDH1A1 1343/4885HTT 4861/4885HDAC1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.